Depression got you Down? Magnetic Brain Therapy to the Rescue!


Yamile Jasaui

Principal Investigator

Dr. Frank MacMaster


University of Calgary

Grant Type




About the researcher


Research Associate at the University of Calgary

The impact

Depression is predicted to be the second-largest contributor to the global disease burden by 2020.  Practically everybody is impacted by depression (directly, or indirectly through loved ones). With such a huge impact, it’s important to understand how depression happens in the brain so that new treatments can be developed. Approximately 30-60% of the people with depression don’t get better with normal antidepressant or psychotherapy treatments, suggesting something is different about their brains. Being able to identify what this key difference is can tell doctors who should receive standard treatments, and who might better benefit from other treatments, like Transcranial Magnetic Stimulation (TMS). This would lead to a more effective distribution of treatment resources for people with depression, saving the healthcare system money by giving people treatments that likely work better for their unique brains.

The study

One feature of the brain that could be different in treatment-resistant depression is the amount of a neurochemical called glutamate. This study investigated if glutamate could be used to figure out who would and would not improve from a TMS treatment. Does TMS possibly help people get better by changing something about glutamate? This study tried to answer that question by giving people with “treatment-resistant depression” TMS therapy, along with a brain scan before and after their TMS treatment. This led researchers to discover that TMS increased glutamate levels in a part of the frontal cortex ( which is important for reasoning and planning), corresponding to improvements in depression. Furthermore, the people who didn’t respond to TMS already had high glutamate levels, so that might be why TMS wasn’t effective for them.

What's next?

About half of the people who receive TMS will respond with at least a 50% decrease in their depressive symptoms. This is fantastic, as all of these people have been told they have treatment-resistant depression (a pretty scary diagnosis – I’m never going to get better?!) but it’s still not enough. Since glutamate was able to identify who would benefit from TMS, this means doctors could potentially use brain scans for a personalized medicine approach to pediatric depression. Additionally, since an increase in glutamate (an excitatory neurotransmitter) was associated with recovery from depression, this suggests TMS might be “jump-starting” the kids’ brains towards healing. The prevalence of depression in our society is increasing, with a significant lifestyle and economic burden for individuals and communities. We need to be better able to recognize and treat the different subtypes of depression and be able to give them treatments that work for the way their brain is wired.

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Lefebvre, D., Langevin, L. M., Jaworska, N, Harris, A. D., Lebel, R. M., Jasaui, Y., Kirton, A., Wilkes, T. C., Sembo, M., Swansburg, R.., MacMaster, F. P. 2017. A pilot study of hippocampal N-acetyl-aspartate in youth with treatment-resistant major depression. Journal of Affective Disorders.

Yang, X. R., Langevin, L. M., Jaworska, N., Kirton, A., Marc Lebel, R., Harris, A. D., Jasaui, Y., Wilkes, T. C., Sembo, M., Swansburg, R. and MacMaster, F. P. 2016. Proton Spectroscopy Study of the Dorsolateral Prefrontal Cortex in Youth with Familial Depression. Psychiatry and Clinical Neuroscience.